ABOUT US
T-knife: NEXT-GENERATION TCR ENGINE

T-knife is set out to revolutionize the TCR landscape with its unique and proprietary transgenic HuTCR mouse platform to produce fully human TCRs. These TCRs mimic the properties of virus-specific TCRs avoiding immunological tolerance to self tumor antigens in humans.

T-knife’s TCRs do not require additional modification but are naturally selected in vivo for an optimal affinity/specificity combination. The Company´s lead TCR has entered clinical development in an academic investigator-initiated study in patients with multiple myeloma.

ABOUT T-knife

T-knife was founded in 2018 by Thomas Blankenstein, Elisa Kieback and Holger Specht as spin-off from Max-Delbruck Center for Molecular Medicine with support of Charité University Hospital in Berlin/Germany and the mission to bring novel, sophisticated T cell receptor-based therapeutics to market. Based on the unparalleled T cell immunology expertise of its founders and the unique and proprietary HuTCR platform, the Company develops fully human TCRs which are expected to set new technology standards achieving superior safety and efficacy.

The Company has demonstrated preclinical proof-of-concept and its lead compound has entered clinical development. In addition, T-knife has validated the platform for over 90 undisclosed cancer targets, with several follow-on drug candidates being already in preclinical development.

T-knife MANAGEMENT
Tom-Soloway_2
Tom Soloway
CEO
Camille-Landis_2
Camille Landis
CBO/CFO
Elisa_Foto
Dr. Elisa Kieback
CTO
eugen3
Prof. Dr. Eugen Leo
CMO
michael_sw
Dr. Michael Buchholz
Director Manufacturing
T-knife BOARD
alexander_mayweg
Alexander Mayweg, PhD
Versant Ventures
josh_resnick
Josh Resnick, MD
RA Capital Management
Ollivier neues Bild
Dr. Olivier Litzka
ANDERA PARTNERS
frank_kalkbrenner
Frank Kalkbrenner
Boehringer Ingelheim Venture Fund
Thomas_Foto
Prof. Dr. Thomas Blankenstein
Scientific Founder of T-knife
Debasish_Foto
Debasish Roychowdhury, MD
Independent Board Member
Elisabeth_Foto
Dr. Elisabeth von Weizsäcker
ASCENION GmbH
markus_einzelberger
Markus Enzelberger, PhD
Versant Ventures
den_marks
Dan Marks, PhD
RA Capital Management
T-knife SCIENTIFIC ADVISORY BOARD
Christopher Klebanoff
Christopher A. Klebanoff, M.D.
Memorial Sloan Kettering Cancer Center
John_Foto
Prof. Dr. John B. Haanen
Netherlands Cancer Institute
Fiona_Foto
Prof. Dr. Fiona Thistlethwaite
University of Manchester
Junghans_Fotor
Richard P. Junghans, PhD, MD
Boston University School of Medicine
Thomas_Foto
Prof. Dr. Thomas Blankenstein
Scientific Founder of T-knife

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