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T-knife: NEXT-GENERATION TCR ENGINE

T-knife is set out to revolutionize the TCR landscape with its unique and proprietary transgenic HuTCR mouse platform to produce fully human TCRs. These TCRs mimic the properties of virus-specific TCRs avoiding immunological tolerance to self tumor antigens in humans.

T-knife’s TCRs do not require additional modification but are naturally selected in vivo for an optimal affinity/specificity combination.

ABOUT T-knife

T-knife was founded in 2018 by Thomas Blankenstein, Elisa Kieback and Holger Specht as spin-off from Max-Delbruck Center for Molecular Medicine with support of Charité University Hospital in Berlin/Germany and the mission to bring novel, T-cell receptor-based therapeutics to market. Based on the unparalleled T-cell immunology expertise of its founders and the unique and proprietary HuTCR platform, the Company discovers fully-human TCRs which have the potential to achieve superior safety and efficacy.

The Company has demonstrated preclinical proof-of-concept. In addition, T-knife has validated the platform for over 90 undisclosed cancer targets, with several follow-on drug candidates currently in preclinical development.

T-knife MANAGEMENT
Tom-Soloway_2
Thomas Soloway
Chief Executive Officer
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Dr. Elisa Kieback
Chief Technology Officer
Camille-Landis_2
Camille Landis
Chief Business Officer/Chief Financial Officer
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Prof. Dr. Eugen Leo
Chief Medical Officer
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Don Wuchterl
Chief Manufacturing Officer
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Dr. Michael Buchholz
Director Manufacturing
T-knife BOARD
alexander_mayweg
Alexander Mayweg, PhD
Versant Ventures
josh_resnick
Josh Resnick, MD
RA Capital Management
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Dr. Olivier Litzka
ANDERA PARTNERS
frank_kalkbrenner
Frank Kalkbrenner
Boehringer Ingelheim Venture Fund
Thomas_Foto
Prof. Dr. Thomas Blankenstein
Scientific Founder of T-knife
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Debasish Roychowdhury, MD
Independent Board Member
T-knife SCIENTIFIC ADVISORY BOARD
Christopher Klebanoff
Christopher A. Klebanoff, M.D.
Memorial Sloan Kettering Cancer Center
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Prof. Dr. John B. Haanen
Netherlands Cancer Institute
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Prof. Dr. Fiona Thistlethwaite
University of Manchester
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Richard P. Junghans, PhD, MD
Boston University School of Medicine
Thomas_Foto
Prof. Dr. Thomas Blankenstein
Scientific Founder of T-knife

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